Prof. K Y FONG (Singapore)

A. Positions and Honors. List in chronological order previous positions, concluding with your present position. List any honors.

Positions and Employment

1980 ¡V 1981

1981 ¡V 1982
1982 ¡V 1985
1985 ¡V 1988
1988 ¡V 1990

1990 ¡V 1992
1992 ¡V 1997
1998 ¡V 1998
1998 ¡V 2003

2003 ¡V 2007


2006 onwards

2007 onwards
2008 onwards
2008 onwards
2008 onwards
House Officer (Internal Medicine, Paediatrics, Orthopaedics),
Tan Tock Seng Hospital (TTSH) and Singapore General Hospital (SGH)
Medical Officer, Ministry of Defence, Singapore
Basic Specialist Trainee in Internal Medicine, TTSH and SGH
Registrar (Medicine), TTSH, SGH and Changi Hospital
Research Fellow, Rheumatology Unit, Royal Postgraduate Medical School, Hammersmith Hospital (UK)
Senior Registrar (Rheumatology), TTSH
Consultant , Dept of Rheumatology and Immunology, TTSH
Senior Consultant, Dept of Rheumatology and Immunology, TTSH
Senior Consultant, Dept of Medicine, National University Hospital and
Associate Professor, Dept of Medicine, National University of Singapore
Head and Senior Consultant, Dept of Rheumatology and Immunology, SGH and Adjunct Associate Professor, Dept of Medicine, National University of Singapore
Chairman, Division of Medicine, SGH and
Senior Consultant, Dept of Rheumatology and Immunology, SGH
Professor (Medicine), Duke-NUS Graduate Medical School
Adjunct Professor, Dept of Medicine, National University of Singapore
Acting Chairman, Division of Research, SGH
Group Director (Clinical Research), Singapore Health Services

Other Experience and Professional Memberships (Selected)

1991 ¡V 1993
1995 ¡V 1998
1998 ¡V 2001
1999 ¡V 2001

2000 ¡V 2003
2004 onwards
2006 ¡V 2007
2006 ¡V 2007
2006 onwards

2008 onwards
Secretary-General, Rheumatism Association of ASEAN Executive Committee
Director, Autoimmune Research Laboratory, Tan Tock Seng Hospital
Chairman, National Arthritis Foundation
Secretary, Biomedical Research and Experimental Therapeutics Society of Singapore
Director, Clinical Trials Unit, National University Hospital
Chairman, Specialist Training Committee (Rheumatology), Ministry of Health
Chairman, Scientific Committee, Asian Autoimmunity Forum
Guest Editor, Annals Academy of Medicine Singapore
Associate Editor, APLAR Journal of Rheumatology (Official Journal of the Asia-Pacific League of Associations for Rheumatology)
Associate Editor, Singapore Medical Journal

Honors
1988 Higher Manpower Development Program Fellowship, Ministry of Health (Singapore)
1989 Arthritis and Rheumatism Council Research Fellowship (UK)
1995 Good Conduct Medal (Military)
2000 Long Service Medal (Military)
2005 Service to Education Award (10-year), Ministry of Education (Singapore)

B. Selected peer-reviewed publications (in chronological order). Do not include publications in preparation.
Selected 5 publications, 94 other peer-reviewed publications available on request.

  1. PCR-RFLP genotyping for exon 1 and promoter region mutations of the human mannose binding lectin (MBL-2) gene. Tin SK, Lee LY, Thumboo J, Koh DR, Fong KY. J Immunol Methods. 2005 Aug;303(1-2):148-51
  2. Novel brain reactive autoantibodies: prevalence in systemic lupus erythematosus and association with psychoses and seizures. Tin SK, Xu Q, Thumboo J, Lee LY, Tse C, Fong KY. J Neuroimmunol. 2005 Dec;169(1-2):153-60
  3. In vivo Pro- and Anti-inflammatory Cytokines in Normal and Patients with Rheumatoid Arthritis. Sivalingam SP, Thumboo J, Vasoo S, Thio ST, Tse C, Fong KY. Ann Acad Med Singapore. 2007 Feb;36(2):96-4
  4. Interleukin-18 Promoter Gene Polymorphisms in Chinese Patients With Systemic Lupus Erythematosus: Association With CC Genotype at Position -607. Xu Q, Tin SK, Sivalingam SP, Thumboo J, Koh DR, Fong KY. Ann Acad Med Singapore. 2007 Feb;36(2):91-5
  5. HLA-DRB1*04 gene polymorphisms and expressions profiles of interleukin-18 and interleukin-18 binding protein following in vitro stimulation in human peripheral blood mononuclear cells of healthy individuals and patients with rheumatoid arthritis. Sivalingam SP, Thumboo J, Vasoo S, Fong KY. Life Sci. 2007 Apr 24;80(20):1887-96
C. Research Support. List ongoing or research projects (competitive and institutional support). Begin with the projects that are most relevant to the research proposed in this application. Briefly indicate the overall goals of the projects and your role (e.g. PI, Co-Investigator) in the research project. List total award amounts for each.

Ongoing Research Support

BMRC (05/1/27/19/418) PI : Fong KY $ 628,500 (2006 ¡V 2009)
Novel Brain Reactive Autoantibodies and Magnetic Resonance Imaging in Systemic Lupus Erythematosus : Potential Pathogenetic Mechanisms in Neuropsychiatric Lupus

NMRC (0840/2004) PI : Fong KY $108,081 (2004 ¡V 2007)
Brain Reactive antibodies in systemic lupus erythematosus : Characterisation of neuronal membrane antigens and correlation with neuropsychiatric manifestations.

Khoo Investigator Award PI : Fong KY $750,000 (2008 ¡V 2011)
Genome-wide gene expression profiles as neuropsychiatric diagnostic markers in systemic lupus erythematosus patients with neurological and cognitive manifestations

NKF Research Fund PI : Fong KY $150,000 (2009 ¡V 2012)
Urinary Biomarkers in Systemic Lupus Erythematosus Patients with Active and Inactive Nephritis