Prof. Jingwu ZANG (China)

Jingwu Zang received his medical degree in Shanghai Second Medical University (now JiaoTong University School of Medicine) and went on to earn his PhD in Immunology in Belgium, where he started his illustrious pursuit of a cure for multiple sclerosis through basic and clinical research. He later received an advanced research fellowship award from US National Multiple Sclerosis Society and conducted his postdoctoral research on multiple sclerosis in Harvard Medical School.

Dr. Zang joined faculty of Neurology and Immunology at Baylor College of Medicine and completed a clinical residency program there. Prior to his career in Shanghai, he had been Professor of Neurology and Immunology, a US-licensed physician and Research Director of Multiple Sclerosis Center at Baylor College of Medicine in Texas. Dr. Zang has published more than 140 scientific articles in prestigious journals, chapters and books. He is well known for his pioneering work in T cell vaccination as a treatment for multiple sclerosis, which led to landmark publications in Science. In his recent career in China, Dr. Zang established the Institute of Health Sciences as the founding director with Chinese Academy of Sciences and JiaoTong University School of Medicine and the Institut Pasteur Shanghai (Chinese Academy of Sciences and Institut Pasteur Paris) as co-director. In June 2007, Dr. Zang joined GlaxoSmithKline as Senior Vice President to head GSK R&D Center in China.

Representative Publications:

  1. Zhang J, Medaer R, Stinissen P, Hafler D, Raus J. MHC-restricted depletion of human myelin basic-protein reactive T-cells by T-cell vaccination. Science 261(5127): 1451- 1454, 1993.
  2. Zang YC, Samanta AK, Halder JB, Hong J, Tejada-Simon MV, Rivera VM, Zhang JZ. berrant T cell migration toward RANTES and MIP-1 alpha in patients with multiple sclerosis - Overexpression of chemokine receptor CCR5. Brain 123: 1874-1882, 2000.
  3. Tejada-Simon MV, Zang YC, Hong J, Rivera VM, Zhang JZ. Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis. Annals of Neurology 53:189-197, 2003.
  4. Sun W, Popat U, Hutton G, Zang YC, Krance R, Carrum G, Land GA, Heslop H, Brenner M, Zhang JZ. Characteristics of T-cell receptor repertoire and myelin-reactive T cells reconstituted from autologous haematopoietic stem-cell grafts in multiple sclerosis. Brain 127(5):996-1008, 2004.
  5. Xu G, Nie H, Li N, Zheng W, Zhang D, Feng G, Ni L, Xu R, Hong J, Zhang JZ. Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. Journal of Clinical Investigation 115(4):1060-1067, 2005.
  6. Hong J, Li N, Zhang X, Zheng B, Zhang JZ. Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3. Proceedings of the National Academy of Sciences USA 102(18): 6449-6454, 2005.
  7. Hong J, Zang YC, Nie H, Zhang JZ. CD4+ Regulatory T Cell Responses Induced by T Cell Vaccination in Patients with Multiple Sclerosis. Proceedings of the National Academy of Sciences USA 103:5024-5029, 2006.
  8. Wang Z, Hong J, Sun W, Xu G, Li N, Chen X, Liu A, Xu L, Sun B, Zhang JZ. Role of Gamma-Interferon in Induction of Foxp3 and Conversion of CD4+CD25- T cells to CD4+ Regulatory T Cells. Journal of Clinical Investigation 116(9):2434-2441, 2006.
  9. Chen G, Li N, Zang YC, Zhang D, He D, Feng G, Ni L, Xu R, Wang L, Shen B, Zhang JZ. Vaccination With Selected Synovial T Cells in Rheumatoid Arthritis. Arthritis and Rheumatism 56(2), 453¡V463, 2007.
  10. Zhang JZ. Yin and Yang interplay of IFN-gamma in inflammation and autoimmune disease. Journal of Clinical Investigation 117(4):871-3, 2007.
  11. Shi Y, Feng Y, Kang J, Liu C, Li Z, Li D, Cao W, Qiu J, Guo Z, Bi E, Zang L, Lu C, Zhang JZ* (Co-corresponding author), Pei G. Critical regulation of CD4+ T cell survival and autoimmunity by £]-arrestin 1. Nature Immunology 8: 817-824, 2007.
  12. Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB, Fang L, Zhao Y, Wan B, Qin X, Lu L, Li R, Pan H, Song M, Liu A, Hong J, Lu H, Zhang JZ. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nature Medicine, 16(2):191-197, 2010.